Obesity
Conditions
Keywords
Obesity, Bariatric surgery
Brief summary
The overall aim is to study the multiple factors determining the variation of weight loss after Roux-en-Y Gastric Bypass (RYGB) and Sleeve surgery. The specific aims are to evaluate: a) what explains the large individual differences in weight loss seen after RYGB and Sleeve surgery, b) if it is possible pre-operatively to identify which patients will not obtain beneficial effects of bariatric surgery in relation to weight loss and quality of life and c) if patients in need of improved care can be identified pre- and/or early post-operatively.
Interventions
PROCEDURERoux-en-Y gastric bypass surgery or sleeve surgery
Sponsors
Bariatric Clinic, Department of Surgery, Køge Hospital, Denmark
The Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Denmark
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients approved for bariatric surgery at Bariatric Clinic, Køge Hospital, Denmark
Exclusion criteria
* Inability to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight loss | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiota | 1 week preoperatively, 6 month postoperatively | — |
| Appetite-regulating hormones | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively | GLP-1, PYY, leptin, ghrelin, OXM, CCK, glicentin |
| Metabolic profile | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively | Insulin, glucose, C-peptide, GIP, glucagon, TSH, thyroid hormones, vitamin D and blood lipids |
| Physical activity | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively | — |
| Appetite sensation | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively | Following a test meal with the use of visual analogue scales (VAS) |
| Taste preferences and taste perception | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively | Sensory tests, picture displays (all visits) and an ad libitum test meals (3 months preoperatively and 6 months postoperatively) are used to investigate changes in taste and food preferences (liking and wanting) and taste perception |
| Social resources | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively | — |
| Bile acids and fibroblast growth factors | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively | — |
| Genetics | 3 month preoperatively | — |
| Body composition | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively | By DXA scans |
| Cortisol | 3 month preoperatively and 18 month postoperatively | Measured in hair |
| Neural activity in reward-processing brain centers | preoperatively and 6 month postoperatively | By functional magnetic resonance imaging (fmri) |
| Rewarding value of food | preoperatively and 6 month postoperatively | Behavioral test |
| Mental health | 3 month preoperatively, 6 month postoperatively and 18 month postoperatively | — |
Countries
Denmark
Outcome results
None listed