Perioperative Recovery of Moods, Opioids, and Pain Trial (PROMPT)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02070003

Acronym

PROMPT

Enrollment

104

Registered

2014-02-24

Start date

2014-11-26

Completion date

2018-08-15

Last updated

2020-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid Cessation

Brief summary

The investigators aim to characterize the relationship between changes in emotional distress, opioid use, and pain throughout surgery and recovery. Additionally, the investigators aim to compare the effectiveness of post-surgical motivational interviewing and physician-guided opioid weaning vs. usual care on reducing persistent opioid use. Overall, the proposed research will advance knowledge regarding the role of psychological factors contributing to persistent opioid use after surgery.

Interventions

BEHAVIORALMotivational Interviewing and Physician Guided Opioid Weaning

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18+ * Undergoing a scheduled surgery * English speaking * Ability and willingness to complete questionnaires and assessments.

Exclusion criteria

* Any conditions causing inability to complete baseline, telephone and internet assessments (e.g. education, cognitive ability, mental status, medical status)at the discretion of the investigator. * Known Pregnancy * Elevated Suicidality as assessed by an answer of 2 or greater on question 9 of the Beck Depression Inventory assessing suicidal thoughts. * Coexisting Chronic Pain Disorder of moderate severity in area other than surgical target

Design outcomes

Primary

Measure	Time frame	Description
Trial Feasibility - The proportion of people consented who complete the study in the group to which they were randomized	Duration of the study - up to 2 years per participant	Factors that contribute to non-completion of the study, measured at baseline for each patient, will be analyzed.

Secondary

Measure	Time frame	Description
Efficacy - time to opioid cessation	Duration of the trial - Up to 2 years per participant	Time to opioid cessation between the two groups will be analyzed using survival analysis

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026