Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02069587

Enrollment

200

Registered

2014-02-24

Start date

2014-02-28

Completion date

2015-04-30

Last updated

2014-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PPROM

Keywords

PPROM, PREGNANCY, POMEGRANATE, OXIDATIVE STRESS

Brief summary

Preterm premature rupture of membrane is associated with increased oxidative stress and inflammatory process, enhancing the activity or the availability of antioxidants may modulate the inflammatory response associated with PPROM, thereby reducing oxidative stress and the risk to the fetus. In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal) oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

Detailed description

In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal )oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

Interventions

DIETARY_SUPPLEMENTpomegranate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 44 Years

Healthy volunteers

Inclusion criteria

* Pregnant patients * admitted with PPROM * between 24-32 weeks of gestation

Exclusion criteria

* Women with contractions * abruption * monochorionic multiple pregnancy * abnormal (non-reassuring) cardiotocogram * meconium-stained amniotic fluid * signs of intrauterine infection * major fetal anomalies * hemolysis * elevated liver enzymes * low platelets (HELLP syndrome); or severe preeclampsia.

Design outcomes

Primary

Measure	Time frame	Description
Maternal and fetal oxidative stress	10 weeks	Maternal and fetal oxidative stress will be determined by blood tests.

Secondary

Measure	Time frame	Description
Time interval from PPROM to delivery	10 weeks	Time interval from PPROM to delivery, respiratory distress syndrome (RDS), meconium aspiration syndrome, asphyxia, late onset neonatal sepsis, hypoglycemia, necrotizing enterocolitis, hyperbilirubinemia, intraventricular hemorrhage, periventricular leucomalacia, convulsions, other neurological abnormalities, other complications, intrapartum death, total length of hospital stay and admission, and length of stay on neonatal intensive care unit (NICU).
time interval from PPROM to delivery	10 weeks	following birth the time interval from PPROM to delivey will be assessed, also RDS, fetal Ph and other neonatal complications

Countries

Israel

Contacts

Primary Contactron beloosesky, M.D

tomor2304@yahoo.com011972509205759

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026