Chronic Respiratory Insufficiency, Intermittent Positive-pressure Ventilation, Neuromuscular Disease
Conditions
Keywords
Neuromuscular disease, Home ventilation, End tidal CO2, Transcutaneous CO2, Monitoring
Brief summary
The purpose of this study is to compare the measure of the CO2 obtained on the end-tidal expiratory gas (ETCO2) with the value of CO2 obtained by transcutaneous measure (PTCO2), in home-ventilated neuromuscular patients.
Detailed description
Monitoring of the effectiveness of ventilation in patients with neuromuscular require to regularly measure blood gases and in particular carbon dioxide (CO2). The reference technique is arterial puncture. In recent years, a non-invasive techniques measuring CO2 by transcutaneous sensor (PTCO2) was introduced among the tools regularly used for follow-up monitoring of home ventilated patients. Another technique for monitoring CO2, originally developed for anesthesia, is based on the measurement of exhaled CO2 (ETCO2). This technique requires relatively simple equipment, and represents a potential alternative for monitoring home-ventilated patients. Recently, sensors for ETCO2 were coupled to devices for home ventilation. To the best of our knowledge, the role of ETCO2 in monitoring long-term ventilated patients has not been investigated to date. The purpose of the study is to analyze the correlation between the two non-invasive methods for measuring CO2: PTCO2 and ETCO2, in a group of home-ventilated patients with neuromuscular disease. The patients will be recruited during a routine follow-up hospitalization for their home-ventilation, and the ETCO2 will be measured during one night, in addition to the routinely measured PTCO2.
Interventions
DEVICEMonitoring of ETCO2 and PTCO2
Concomitant monitoring of ETCO2 and PTCO2
Sponsors
Centre d'Investigation Clinique et Technologique 805
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with neuromuscular disease, treated with home invasive or non-invasive ventilation * Male or female age higher or equal to 18 years * Negative pregnancy test for women of childbearing age or having an effective contraception
Exclusion criteria
* Acute Respiratory Failure * Long-term oxygen therapy * Refusal to participate in the study * Plan of legal protection * Pregnant Women * Failure to cooperate * No affiliation to a social security scheme
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| concordance between the nocturnal average values of ETCO2 and PTCO2 | one night | concordance between the nocturnal average values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| concordance between the nocturnal maximal values of ETCO2 and PTCO2 | one night | concordance between the nocturnal maximal values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 |
| concordance between the variation of the values of ETCO2 and PTCO2 | one night | concordance between the variation of the values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 |
| concordance between the values of ETCO2, PTCO2 and arterial CO2 (PaCO2) measured at the same time | one night | concordance between the values of ETCO2, PTCO2 and arterial CO2 (PaCO2) measured at the same time |
Other
| Measure | Time frame | Description |
|---|---|---|
| influence of circuit leakage on the gradient between PaCO2 and ETCO2 | one night | evaluate the influence of circuit leakage on the gradient between PaCO2 and ETCO2 |
Countries
France
Outcome results
None listed