Roux-en-Y Gastric Bypass
Conditions
Brief summary
It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.
Interventions
PROCEDURERoux-en-Y Gastric Bypass
Sponsors
Rijnstate Hospital
Wageningen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital
Exclusion criteria
* Lack of appetite * Having difficulties swallowing/eating * Being a vegetarian * Allergic to food product used as stimuli in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development of food preferences after Roux-en-Y gastric bypass surgery | Participants will be followed for two years after they undergo surgery | Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery. |
| Change in brain reward response to food cues | Before and 2 months after surgery | Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma levels of endocannabinoids and satiety hormones | Before and 2 months after surgery | Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Descriptives | Before surgery | General subject characteristics, e.g. age, gender, restrained eating score and other lifestyle and medical parameters. For the subset of 30 patients that participate in the fMRI measurements: disinhibition scores will be assessed. |
| Development of BMI | Before and after surgery | — |
| Appetite ratings | During fMRI measurements, i.e., before and two months after surgery | In a subset of 30 participants. |
| Olfactory performance | At each fMRI measurement, i.e., before and two months after surgery | The Sniffin' Sticks test will be used to assess olfactory performance in the subset of 30 participants that will participate in the fMRI measurements. The sum-score of threshold, discrimination and identification tests will be used to determine if a participant is normosmic. A score of \> 30 indicates a participant is normosmic. |
Countries
Netherlands
Outcome results
None listed