Pain
Conditions
Keywords
acetaminophen intravenous oral pain scores opioids
Brief summary
Both intravenous and oral acetaminophen have been shown to reduce post-operative pain scores when given preoperatively. This study investigates if there is a difference between the intravenous and the oral forms when given preoperatively to patients undergoing lumbar microdiscectomy. We hypothesize that the intravenous formulation does not improve pain scores or decrease opioid consumption during the first postoperative day compared to the oral formulation.
Interventions
1000 milligrams given orally before surgery
1000 milligrams of intravenous acetaminophen given before surgery
Sponsors
Thomas Jefferson University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Single level lumbar micro disk surgery * Ages 18-65
Exclusion criteria
* morbid obesity * prior back surgery * opioid tolerance * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain scores | Day of surgery | Pain scores are measured using a visual analog scale with patient at rest and also with movement of the lower extremities at four separate times following surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantity of intraoperative and postoperative opioids administered. | Day of surgery | All doses of opioids given on the day of surgery will be recorded. |
Countries
United States
Contacts
Primary ContactMarc D Fisicaro, MD
Outcome results
None listed