Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery

The Effect of Epidural Low-dose Morphine-soaked Microfibrillar Collagen Sponge in Postoperative Pain Control After Posterior Lumbar Spinal Surgery: a Randomized, Double-blind, Placebo-controlled

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02067338

Enrollment

Registered

2014-02-20

Start date

2012-08-31

Completion date

2014-01-31

Last updated

2014-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morphine

Brief summary

The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study

Interventions

DRUG1 mg morphine soak in epidural oxidized cellulose

During posterior lumbar spinal surgery , patients received 1 mg morphine-soaked in epidural oxidized cellulose.

DRUGnormal saline

During posterior lumbar spinal surgery , patients received NSS -soaked in epidural oxidized cellulose.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Age \> 18 Yrs * Good orientation and communication

Exclusion criteria

* opioids or sulfonamides allergy * Contraindication for use * Epidural morphine * Selective COX 2 inhibitor * Patient-controlled analgesia (PCA) * ASA class \> 3 * BMI ≥ 35 kg/sq.m. * Preoperative use of opioids within 6 Wks * Intraoperative bleeding \> 1000ml

Design outcomes

Primary

Measure	Time frame
VAS measurement was recorded at twenty-four hour after posterior lumbar spinal surgery then compare VAS between low-dose 1 mg morphine-soaked microfibrillar collagen sponge method with normal saline soked	2 years

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026