Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Basic Research on Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02066558

Enrollment

Registered

2014-02-19

Start date

2014-02-28

Completion date

2014-12-31

Last updated

2015-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache, Migraine

Keywords

Carbon monoxide, Headache, Migraine

Brief summary

In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.

Detailed description

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Interventions

OTHERCarbon monoxide

carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass.

OTHERPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers * Aged 18-50 * 50-100 kg

Exclusion criteria

* Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * Smoking * Primary relatives with current or previous migraine

Design outcomes

Primary

Measure	Time frame	Description
Headache scores	12 h	Comparison between carbon monoxide and placebo (atmospheric air)

Secondary

Measure	Time frame	Description
Artery circumference	0-180 min	Carbon monoxide induced changes in the superficial temporal artery and the radial artery before and after inhalation.
Facial blood flow	0-180 min	Carbon monoxide induced changes in facial blood flow before and after inhalation.
Blood flow velocity	0-180 min after inhalation	Carbon monoxide induced changes in blood flow velocity in the middle cerebral artery before and after inhalation.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026