Periodontal Diseases
Conditions
Keywords
Ozone gel, Antioxidants, Chronic periodontitis, Superoxide dismutase
Brief summary
To evaluate the efficacy of locally delivered ozone gel as an adjunct to conventional periodontal therapy on selected clinical parameters as well as alveolar bone density (BD) and superoxide dismutase (SOD) activity in patient with chronic periodontitis.
Detailed description
In this study, the investigators tested the effect of ozone gel as a local delivery system in treatment of chronic periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, a more rise in BD values as well as greater reduction in SOD activity compared to scaling and root planing (SRP) alone.
Interventions
Sponsors
October 6 University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. The participant's age ranged between 30 and 60 years. 2. All of the patients suffered from chronic periodontitis with attachment loss ≥ 5mm. 3. Willingness to participate and sign the informed consent.
Exclusion criteria
1. Any systemic disease that affect the periodontium. 2. Pregnancy, lactation, postmenopausal women 3. People who take anti-inflammatory drugs, antibiotics or vitamins within the previous 3 month. 4. People who use mouth washes regularly 5. Heavy smoking (\> 10 cigarettes/day) 6. History of alcohol abuse. 7. Participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Superoxide dismutase activity | 6 months | Superoxide dismutase activity in the gingival crevicular fluid was carried out at baseline, 1, 3 and 6 months post treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plaque Index | 6 months | plaque index was recorded at baseline and at 1, 3 and 6 months post treatment. |
| Gingival index | 6 months | Gingival index was recorded at base line,1,3,6 months post treatment |
| Probing pocket depth | 6 months | Probing pocket depth was recorded at base line, 1, 3, 6 months post treatment |
| Clinical attachment level | 6 months | Clinical attachment level was recorded at baseline, 1, 3 and 6 months post treatment |
| Bone density | 6 months | Bone density was carried out using Digora software (Digora system, Soredex, Orion Corp., Finland) at baseline and 6 months |
Countries
Egypt
Outcome results
None listed