Chronic Heart Failure, Pulmonary Disorder, Chronic Obstructive
Conditions
Keywords
digestion, absorption, protein, amino acids, heart failure, COPD
Brief summary
The aim of the present study is to validate a new method in healthy volunteers and those diagnosed with COPD and CHF that is able to measure protein digestion and absorption simultaneously. This method is used to quantify digestion and absorption in patients who are suspect of impaired digestion and absorption resulting in loss of nutrients.Findings may be used to develop treatment strategies to improve protein digestion and absorption in these patient groups.
Detailed description
The study involves 1 screening visit of approximately 1-2 hours and 1 test day of approximately 8 hours. On the study day protein digestion and absorption will be measured using a mixture of amino acids that are made slightly heavier than normal, called stable isotopes. Subjects will receive feeding by sips to monitor changes in digestion and absorption, which can be picked up by stable isotope technology.
Interventions
such as glycerol, D2O, tyrosine, phenylalanine, glucose, arginine, and citrulline
Sponsors
Texas A&M University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
IInclusion and
Exclusion criteria
for study participation: We will enroll subjects (males and females of all races) based on the inclusion/
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| protein metabolism in gut | In postabsorptive and prandial state every 20 minutes up to 8 hours before each sip feeding on study day | Digestion of the stable tracers of amino acid measured by plasma samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body Composition | on screening or study day 1 | Body composition as measured by Dual-Energy X-ray Absorptiometry |
| Respiratory muscle strength | on study day 1 | determined by measurement of maximum breathing pressures |
| Skeletal muscle strength of hand | 30 minutes on screening or study day | measurement of handrip strenth |
| Skeletal muscle strength of leg | 30 minutes on screening or study day | measurement of muscle strength of leg using kin-com machine |
Countries
United States
Outcome results
None listed