Gastric Neoplasia, H.Pylori, Intestinal Metaplasia, Mucosal Microbiome
Conditions
Keywords
mucosal microbiome, H.pylori, intestinal metaplasia, gastric neoplasia, endomicroscopy
Brief summary
There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.
Detailed description
The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.
Interventions
Sponsors
Shandong University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for gastroendoscopy examination * Aged between 18 and 80 years old
Exclusion criteria
* Antibiotic, probiotic or prebiotic usage within 2months * Esophageal, gastric or duodenal cancer or other malignancy * History of upper GI tract surgery * Coagulopathy or bleeding disorders * Allergy to fluorescein sodium * Pregnant or breast-feeding (for females) * Impaired renal function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The operational taxonomy units in gastric mucosal microbiome | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| The diagnostic accuracy of endomicroscopy compared to pathology. | 6 months |
Countries
China
Outcome results
None listed