Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02063919

Enrollment

Registered

2014-02-17

Start date

2013-11-30

Completion date

2014-06-30

Last updated

2015-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Inflammation, Colorectal Neoplasia, Hyperplasia, Mucosal Microbiome

Brief summary

The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.

Detailed description

The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.

Interventions

OTHERthe mucosal microbiome in the biopsy specimen was analysed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 years old ≤ age \< 80 years old * Scheduled for colonoscopy in Qilu Hospital

Exclusion criteria

* antibiotic usage within 2 months * probiotic or prebiotic usage within 2 months * ascites * jaundice * liver cirrhosis * impaired renal function * coagulopathy * fever * pregnancy * breastfeeding * inability to provide informed consent * known allergy to fluorescein sodium

Design outcomes

Primary

Measure	Time frame
The operational taxonomy unit in the colorectal mucosal microbiome.	6 months

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026