Fracture of Lower Limb, Knee Osteoarthritis, Necrosis of Femoral Head
Conditions
Keywords
Postoperative cognitive changes, Acetylcholine in CSF, Surgery
Brief summary
Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elder than 60 years old * Spoke proficient Mandarin Chinese * Agree to undergoing spinal plus general anesthesia * Selected total knee replacement surgery
Exclusion criteria
* Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis * Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * Unwillingness to comply with the protocol or procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short-term postoperative cognitive dysfunction rate | The day before surgery and 7 days after surgery (or before leave hospital) |
| Concentration of Acetylcholine in CSF | During spinal anesthesia |
| Concentration of choline acetyltransferase in CSF | During spinal anesthesia |
| Concentration of acetylcholinesterase in CSF | During spinal anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Long-term postoperative cognitive dysfunction rate | Two months after surgery |
Countries
China
Outcome results
None listed