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Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Multicenter Registry of Chronic Total Occlusion Interventions

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02061436
Acronym
PROGRESS-CTO
Enrollment
2000
Registered
2014-02-12
Start date
2012-01-01
Completion date
2030-01-01
Last updated
2026-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

chronic total occlusion, percutaneous coronary intervention

Brief summary

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to determine the frequency of CTO PCI performed at the participating sites and examine the procedural strategies utilized, and the procedural (both immediate and during follow-up) outcomes.

Interventions

None listed

Sponsors

Minneapolis Heart Institute Foundation
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Patients undergoing CTO PCI at each of the participating centers.

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
procedural success of chronic total occlusion PCIdischarge from the hospital after PCI, which usually happens the day after the procedureProcedural success is defined as achievement of technical success with no in-hospital major adverse cardiac events (MACE). In-hospital MACE includes any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.

Secondary

MeasureTime frameDescription
technical success of chronic total occlusion PCIdischarge from the hospital after PCI, which usually happens the day after the procedureTechnical success of CTO PCI was defined as successful CTO revascularization with achievement of \<30% residual diameter stenosis within the treated segment and restoration of TIMI grade 3 antegrade flow.
major adverse cardiovascular eventsdischarge from the hospital after PCI (which usually happens the day after the procedure) and during clinically-indicated follow-up. There are no pre-specified follow-up time periods - patients are assessed if and when they come to receive clinical care.In-hospital major adverse cardiovascular events (MACE) include any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke. MACE during clinical follow-up include death, myocardial infarction, target lesion and target vessel revascularization.

Countries

Canada, Egypt, Greece, Lebanon, Russia, United States

Contacts

CONTACTEmmanouil S Brilakis, MD, PhD
esbrilakis@gmail.com(214) 857-1547
PRINCIPAL_INVESTIGATOREmmanouil S Brilakis, MD, PhD

Minneapolis Heart Institute Foundation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 20, 2026