Septic Shock
Conditions
Keywords
Septic shock, Early goal directed therapy, Fluid resuscitation, Hepatic perfusion, Indocyanine Green
Brief summary
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
Detailed description
Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.
Interventions
None listed
Sponsors
Zhongda Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. patients with septic shock 2. at least one of the EGDT criteria not achieved 3. informed consent accepted
Exclusion criteria
1. ages below 18 or above 90 2. pregnancy 3. the time elapsed over 24 hours after onset of septic shock 4. chronic liver disease 5. terminal stage of disease 6. brain death 7. other types of shock 8. brain injury 9. allergic to iodine or indocyanine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT. | 30 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28 days mortality | 28 days | Follow up to determine the mortality in 28 days after inclusion |
Countries
China
Contacts
Primary ContactXiaohua Qiu, MD
Outcome results
None listed