Parkinson Disease
Conditions
Keywords
Parkinson disease
Brief summary
The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease. Observational study case-only
Detailed description
Objectives 1. how many patients will experience motor or nonmotor fluctuation during follow-up period? 2. in how many patients, does motor fluctuation precede nonmotor fluctuation? 3. in how many patients, does nonmotor fluctuation precede motor fluctuation? Participants: persons with Parkinson disease in early stage who does not have motor or nonmotor fluctuation Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for each participants
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria * early stage
Exclusion criteria
* dementia (MMSE\<26) * persons who refuse participating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time period from the onset of disease to the occurrence of motor or nonmotor fluctuation | 6 months | The proportion of participants with motor and/or nonmotor fluctuation will be evaluated at 6, 12, 18, 24, 30, and 36 months after the enrollment of each participant in order to determine the time course of motor/nonmotor fluctuation in persons with early stage of Parkinson's disease. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity and specificity of self-diagnostic questionnaire of motor/nonmotor fluctuation | 3 years | The participants will be checked regularly for the development of motor/nonmotor fluctuation during study period by both of self-diagnostic questionnaire and clinician. The validation of self-diagnostic questionnaire of motor/nonmotor fluctuation will be conducted compared to the clinician-evaluated occurrence of motor/nonmotor fluctuation. |
Other
| Measure | Time frame | Description |
|---|---|---|
| The proportion of participants with impulse control disorders | 6 months | The presence of impulse control disorders including excessive shopping, binge eating, pathologic gambling, and hypersexuality will be checked with questionnaire at 6, 12, 18, 24, 30, and 36 months in order to determine the frequency of impulse control disorders among the participants |
| The proportion of participants with rapid eye movement (REM) sleep behavior disorder | 6 months | The presence of REM sleep behavior disorder will be checked with questionnaire at 6, 12, 18, 24, 30, and 36 months in order to determine the frequency of REM sleep behavior disorder among the participants. |
| The proportion of participants with smoking history | 6 months | The smoking history will be checked with questionnaire at 6, 12, 18, 24, 30, and 36 months in order to determine the influence of the smoking history to development of motor/nonmotor fluctuation. |
Countries
South Korea
Contacts
Primary ContactBeom S Jeon, MD, PhD
Outcome results
None listed