Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02060591

Enrollment

Unknown

Registered

2014-02-12

Start date

2014-01-31

Completion date

Unknown

Last updated

2014-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty

Brief summary

The Investigators aim to study the efficacy of Exparel as compared to Marcaine, taking into account pain control, narcotic consumption, narcotic-related side effects, outcomes measures, and patient satisfaction. Moreover, the Investigators plan to perform cost-benefit analysis to evaluate whether use of Exparel decreases analgesic consumption, duration of hospital stay and the need for physical therapy postoperatively, therefore, offsetting its higher price in comparison with Marcaine.

Interventions

DRUGExparel

DRUGMarcaine

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

All patients at least 18 years old who have primary unilateral TKA for osteoarthritis performed at Thomas Jefferson University Hospital.

Exclusion criteria

* American Society of Anesthesiologist (ASA) score of 4 or higher * Hepatic disease (contraindication for acetaminophen) * Renal disease (contraindication for NSAIDs) * Any contraindication for oxycodone, ketorolac, epinephrine, pregabalin, gabapentin, hydromorphone, Tramadol, morphine or other narcotics that are considered as part of routine postoperative pain control protocol * Fibromyalgia * Any contraindication for intrathecal opioid injection * History of substance abuse during the last 2 years * History of allergy to amide compounds * Current consumption of monoaminoxidase (MAO) inhibitors and tricyclic antidepressant (TCA) medications * Allergy to metabisulfite compounds * Chronic use of opioid medications in the month prior to surgery (leads to opioid tolerance and/or opioid-induced hyperalgesia) * Body weight\<50 Kg, BMI\>40 Kg/m2 * History of hypotension * Patients with any surgery related complication in the first 4-6 weeks following TKA, such as infection or mechanical failure

Design outcomes

Primary

Measure	Time frame
2. Measure pain intensity score (pre and post-operatively) by visual analogue scale (VAS) method	Within first 30 days post-operatively

Countries

United States

Contacts

Primary ContactTiffany Morrison, MS, CCRP

tiffany.morrison@rothmaninstitute.com267-339-7818

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026