Ageing, Photo-aging
Conditions
Keywords
Anti-aging, High-flavanol cocoa
Brief summary
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.
Interventions
DIETARY_SUPPLEMENTCocoa flavanol beverage
DIETARY_SUPPLEMENTPlacebo beverage
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy females aged ≥ 40 years * Facial wrinkle grade ≥ 2
Exclusion criteria
* received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study * reported taking functional foods 1 month before the study * history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes * history of allergies against any component of trial foods * any visible skin disease that might be confused with a skin reaction to the test procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in skin wrinkles at week 24 | baseline, week 24 | Facial wrinkles in the crow's feet area measured as R1-3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in skin elasticity at week 24 | baseline, week 24 | Facial elasticity measured as R2, R5, R7 |
| Change from baseline in minimal erythema dose at week 24 | baseline, week 24 | — |
| Change from baseline in skin hydration at week 12 | baseline, week 12 | Skin hydration measured by Corneometer |
| Change from baseline in skin color at week 12 | baseline, week 12 | Skin color measured as erythema index and melanin index |
Countries
South Korea
Outcome results
None listed