Atrial Fibrillation, Recurrence
Conditions
Keywords
Atrial fibrillation, Recurrence, CFAE, linear ablation
Brief summary
While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for paroxysmal and persistent atrial fibrillation (AF), different additional ablation approaches are used for substrate modification: linear lesions, ablation of complex fractionated atrial electrograms (CFAE) or a combination of both. The aim of this study is to determine whether there is a difference in terms of freedom from arrhythmia recurrence between PVI with CFAE ablation in combination or not with linear lesions in patients with persistent AF.
Interventions
PROCEDUREPVI+CFAE+DCC
pulmonary vein Isolation (PVI), CFAE for substrate modification and direct current cardioversion (DCC) if AF persists
PROCEDUREPVI, CFAE, anterior and roof line, DCC
PVI, CFAE ablation. If AF persists linear lesions (anterior and roof line), cardioversion if AF persists
Sponsors
Deutsches Herzzentrum Muenchen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with symptomatic persistent AF * After PVI +CFAE ablation, no termination into sinusrhythm or atrial tachycardia
Exclusion criteria
* Left atrial thrombus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Freedom from atrial arrhythmia | 12 months | Documented freedom from atrial arrhythmia (AF or AT) recurrence |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Procedural and safety data | 12 months | Duration of procedure, ablation time, fluoroscopy time and complications |
| Number and result of reablation procedure | 12 months | Number of redo procedures, results and type of recurrent arrhythmia |
Countries
Germany
Outcome results
None listed