Retinal Hypoxia
Conditions
Brief summary
The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
Interventions
DRUGCOX-inhibitor
Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
DRUGNitroglycerin
Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated
DRUGCOX-inhibitor + Nitroglycerin
Combination of COX-inhibitor and nitroglycerin interventions.
Sponsors
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between \>19 and \<61 years * No known systemic or ocular diseases
Exclusion criteria
* Cardio-vascular disease * Lung disease * Epilepsy * Previous ocular disease * Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins * Daily intake of medicine except contraceptive pills * Pregnancy or breastfeeding * Known allergy against any of the drugs used in the interventions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diameter changes of retinal vessels | Examination day 1 and 2 | Comparing the differences of diameter changes occuring during each of interventions |
Countries
Denmark
Outcome results
None listed