Infant Development
Conditions
Keywords
Infant Nutrition, Magnetic resonance spectroscopy, Infant Brain Development, Diffusion weighted Imaging, Diffusion tensor tractography
Brief summary
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
Detailed description
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
Interventions
None listed
Sponsors
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
University of Illinois at Urbana-Champaign
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 4 Months
Healthy volunteers
Yes
Inclusion criteria
* full-term babies whose mothers have no known medical conditions or complications during pregnancy.
Exclusion criteria
* preterm babies * babies whose mothers have significant medical conditions and/or significant complications during pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function | Infants receive an MRI at 3 months of age |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional analysis of mothers diet using a food frequency questionnaire | Mothers fill out questionnaire at three months after enrollment into the study |
Other
| Measure | Time frame |
|---|---|
| Mullen Early scales of Learning (MSEL) test | This test is conducted with the infants at 3 months of age prior to the month MRI scan. |
Countries
United States
Outcome results
None listed