Healthy Children, Vernal Keratoconjunctivitis
Conditions
Keywords
Vernal keratoconjunctivitis, Cytokines, Mediators, Tears
Brief summary
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
Detailed description
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
Interventions
PROCEDURECytokins assay in tears
Sponsors
University Hospital, Clermont-Ferrand
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Childrens between 3 and 18 years * Affiliated at system of French social security * Signed by the holders of parental authority of the sheet and written consent to participate in this study * First consultation at Clermont-Ferrand Hospital for vernal keratocunjunctivitis
Exclusion criteria
* Subject suffering from acute or chronic eye disease in which the physician investigator resound with the results: uveitis, glaucoma, retinopathy * Subject who had undergone eye surgery * Subject having an infection the day of collection: ENT, digestive, urinary * Subject with cancer, mental illness or any other condition in which the physician investigator sound informed consent and / or the results * Pregnant subject * Subject with contact lenses * Subject who judged by the investigating physician not enough cooperating to allow a safe collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of 40 cytokines in tears | at time 0 | Comparaison of concentration of 40 cytokines in tears between healthy children and children with vernal keratoconjunctivitis |
Secondary
| Measure | Time frame |
|---|---|
| Validation of normal range of cytokines in tears of healthy children | at 6 month |
| Modification of the inflammatory profile according to the clinical severity and treatment | at 6 month |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed