Brain Tumour
Conditions
Keywords
supratentorial brain tumour, craniotomy
Brief summary
Anterior scalp block with 0.5% plain Marcaine 20 ml. may reduce the intraoperative opioid consumption in neurosurgical patients who undergoing the supratentorial craniotomy compared to those who receive 0.9% normal saline solution (placebo).
Detailed description
Anterior scalp block with 0.5% plain Marcaine 20 ml. may reduce the intraoperative opioid consumption in neurosurgical patients who undergoing the supratentorial craniotomy compared to those who receive 0.9% normal saline solution (placebo). A Prospective Randomized Double Blind Control
Interventions
Anterior scalp block will be done by using 0.5% plain Marcaine 20 ml.
DRUGScalp block with 0.9% normal saline
Anterior scalp block will be done by using 0.9% normal saline 20 ml.
Sponsors
Chiang Mai University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients who have supratentorial brain tumor 2. Patients have been scheduled to undergo an elective craniotomy to remove tumor in any surgical position 3. Patients have been general anesthetized with endotracheal intubation and control ventilation 4. Patients who have provided consent for the participation in the research and for the use of their medical record in research
Exclusion criteria
1. Pregnant patients 2. Patients who have a history of local anesthetic allergy and/ or anaphylaxis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative opioid consumption | During the supratentorial craniotomy surgery | The overall intravenous fentanyl consumption (microgram/ kilogram) during the surgery. The decision to administer fentanyl is guided by the changes of blood pressure and/ or heart rate greater than 20% from baseline level. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| systolic blood pressure change | within 5 minutes after skull pin insertion | The maximal systolic blood pressure within the first 5 minutes after skull pin insertion will be recorded. The systolic blood pressure change from baseline will be calculated. The unit is mmHg. |
| Heart rate change | within 5 minutes after skull pin insertion | The maximal heart rate within the first 5 minutes after skull pin insertion will be recorded. The heart rate change from baseline level will be calculated. The unit is beats per minute. |
Other
| Measure | Time frame | Description |
|---|---|---|
| extubation | end of surgery, before transferring to the intensive care unit | The rate of immediate extubation before transferring to the intensive care unit (ICU) compared between patients who received 0.5% plain Marcaine and 0.9% normal saline solution. |
Countries
Thailand
Outcome results
None listed