Skip to content

HEART Pathway Implementation

The HEART Pathway: Bridging the Gap Between Operations, Research, and Education

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02056964
Enrollment
14717
Registered
2014-02-06
Start date
2013-11-30
Completion date
2019-01-31
Last updated
2019-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome, Chest Pain, Chest Pain Atypical Syndrome, Chest Pain Rule Out Myocardial Infarction

Keywords

Acute Coronary Syndrome, Chest Pain, Risk Stratification, Clinical Decision Aid, Emergency Department, Low Risk Chest Pain, Non Cardiac Chest Pain

Brief summary

The purpose of this study is to determine the effectiveness of the HEART Pathway, a clinical decision aid for the care of patients with chest pain, in a real-world clinical setting. This will be accomplished through the building of a transformative collaboration between research, education, and health systems operations to more effectively and efficiently provide patient care.

Detailed description

Millions of patients with chest pain are seen in Emergency Departments (EDs) every year. Over half of ED patients with chest pain are admitted to the hospital to undergo further testing. Despite high testing rates, less than 1 in 10 patients with chest pain are ultimately diagnosed with an acute coronary syndrome (ACS) at estimated annual cost of $13 billion. Current care patterns for acute chest pain fail to focus health system resources, such as hospitalization and cardiac testing, on patients most likely to benefit. The HEART Pathway, which combines a clinical decision aid, with two serial troponin measurements, has been developed to identify patients with chest pain who can safely be discharged without objective cardiac testing (stress testing or angiography). Prior retrospective and observational studies have established that use of the HEART Pathway reduces cardiac testing by \>20%, while maintaining an acceptably low adverse event rate. We now seek to integrate the HEART Pathway into real-world clinical settings to determine effectiveness. The goal of this proposal is to build a transformative collaboration bridging the gap between research, education, and health systems operations to more effectively and efficiently provide patient care. The vanguard for this collaboration seeks to improve quality of care for patients with acute chest pain by integrating the HEART Pathway into cardiovascular care delivery at Wake Forest Baptist Health (WFBH). This project will build on our prior work and provide a model for using the education and operational strengths of US academic medical centers to disseminate initiatives to improve care delivery.

Interventions

None listed

Sponsors

Association of American Medical Colleges
CollaboratorOTHER
Donaghue Medical Research Foundation
CollaboratorOTHER
Wake Forest University Health Sciences
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age greater than or equal to 21 years of age at the time of Emergency Department (ED) visit * Chest discomfort consistent with possible Acute Coronary Syndrome (ACS) as indicated by the treating physician obtaining an Electrocardiogram (ECG) and cardiac biomarkers for the patient's evaluation.

Exclusion criteria

* New ST-segment elevation in contiguous leads on any electrocardiogram (\>/= 1 mV)

Design outcomes

Primary

MeasureTime frame
Hospitalization rate30 Days after Emergency Department Visit

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026