Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02056821

Enrollment

Registered

2014-02-06

Start date

2014-02-28

Completion date

2016-05-31

Last updated

2017-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke

Keywords

stroke, transcranial doppler, cerebral blood flow, cardiac output, non-invasive hemodynamic monitoring

Brief summary

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Suspected ischemic stroke within 12 hours of symptom onset * NIHSS ≥ 4 * Age 18 to 90 years

Exclusion criteria

* Baseline modified Rankin Scale \> 3 * Pregnancy * Intracranial hemorrhage on head CT * Mechanical ventilation prior to enrollment * Inadequate temporal windows for TCD analysis

Design outcomes

Primary

Measure	Time frame	Description
Change in cerebral blood flow velocities	initial 24 hours	Cerebral flow velocities determined by bilateral MCA measurements by TCD

Countries

United States

Outcome results