Anesthetic Efficacy in Irreversible Pulpitis

Anesthetic Efficacy of Articaine, Lidocaine and Mepivacaine in Patients With Irreversible Pulpitis of Mandibular Molar

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02054767

Enrollment

Registered

2014-02-04

Start date

2010-08-31

Completion date

2013-07-31

Last updated

2014-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

articaine, lidocaine, mepivacaine, inferior alveolar nerve block, irreversible pulpitis

Brief summary

The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.

Detailed description

Conventional inferior alveolar nerve block (IANB) is the most commonly used technique for achieving pulpal anesthesia in posterior mandibular endodontic procedures. However, IANB has a high failure rate and success rates are even lower when applied for the treatment of mandibular posterior teeth with irreversible pulpitis.

Interventions

DRUGIntervention: inferior alveolar nerve block injection

-22 patients received inferior alveolar nerve block injections of 3.6 mL (equivalent to 2 cartridges)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* clinical diagnosis of irreversible pulpitis * good health * had at least 1 adjacent tooth plus a healthy canine

Exclusion criteria

* took medication could be interacting with any of the anesthetics used

Design outcomes

Primary

Measure	Time frame	Description
pulpal anesthesia	Ten minutes after the inferior alveolar nerve block	pulpal anesthesia was tested with an electric pulp stimulator

Secondary

Measure	Time frame	Description
analgesia	the patients were instructed to report any painful sensation at three phases: 1) dentin 2) pulp chamber 3) root canal	To evaluate the intensity of pain during the pulpectomy a verbal analogic scale was adopted

Other

Measure	Time frame	Description
lip anesthesia	ten minutes after the inferior alveolar nerve block	The investigators evaluated the subjective lip anethesia by asking the patient whether his/her lip was numb

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026