Healthy
Conditions
Keywords
magnetic resonance spectroscopy, quantification precision, brain, brain metabolites
Brief summary
Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile"). The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla). Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision. Aims 1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla). 2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla). Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).
Interventions
None listed
Sponsors
University of Minnesota
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* over 18 years old
Exclusion criteria
* no metallic implant or other MRI-incompatible device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Precision of quantification of brain metabolites concentrations | One time only | This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORPierre-Gilles Henry, PhD
Center for Magnetic Resonance Research, University of Minnesota
Outcome results
None listed