Appetite, Energy Intake
Conditions
Keywords
appetite, overweight, energy intake, obesity, gut hormones
Brief summary
The purpose of this study is to investigate the effect of eating various levels of mycoprotein (Quorn) on feelings of appetite, energy intake and levels of gut hormones in overweight volunteers.
Detailed description
Owing to its relatively high protein and fibre content, mycoprotein presents an attractive food product to improve appetite regulation and postprandial glycaemic and insulin responses in overweight and obese individuals at risk of developing T2DM
Interventions
DIETARY_SUPPLEMENTmycoprotein
DIETARY_SUPPLEMENTcontrol protein
Sponsors
Imperial College London
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females between the ages of 18 and 65 * body mass index (BMI) 25-32kg/m2 * Weight stable over the past 6 months * No known major illness or eating disorder nor on any medication that may impact on appetite or hormone levels. * No paracetamol or other analgesic in the previous 48 hours * A score of \<2.5 in the Dutch Eating Behaviour Questionnaire (DEBQ) * A score of \<2 in the SCOFF questionnaire
Exclusion criteria
* Persons outside the age and BMI ranges stated above * Pregnant and lactating women * Weight variation of greater than 5% in the last 6 months * Any diagnosed major illness * Any paracetamol or analgesic intake in the last 48 hours * Diagnosed eating disorder * Allergy to mycoprotein or mushrooms * Regular consumption of Quorn products * Dislike of any of the test foods or drinks * A score of \>2.5 in the Dutch Eating Behaviour questionnaire * A score of 2 or more in the SCOFF questionaire
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy intake at ad-libitum meal | upon completion of all participants, expected timeframe: 2 years | Energy intake will be assessed during an ad-libitum meal at 180 minutes at the end of each study visit. Participants will be offered a meal in excess and asked to eat until they feel comfortably full. The meal will be weighed before and after consumption and energy intake will be calculated from the manufacturer's reported nutritional composition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glucagon-like peptide-1 (GLP-1) | upon completion of all participants, expected at 2 years | Plasma glucagon-like peptide-1 (GLP-1) concentrations will be measured by radioimmunoassay (RIA) at the end of the study |
| peptide tyrosine-tyrosine (PYY) levels | upon completion of all participants, expected at 2 years | Plasma peptide tyrosine-tyrosine (PYY) concentrations will be measured by radioimmunoassay (RIA) at the end of the study |
Countries
United Kingdom
Outcome results
None listed