Heart Failure
Conditions
Brief summary
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.
Interventions
None listed
Sponsors
University of Alberta
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Group 1 No clinically overt heart failure * Group 2 Known coronary artery disease * Group 3 Known heart failure with preserved ejection fraction * Group 4 Known heart failure with reduced ejection fraction * Group 5 Healthy age-matched controls
Exclusion criteria
* Age \<18 years * Known malignancy with expected survival \<1 year * Pregnant or recent pregnancy \<6 months * Recent event (\<2 weeks since Acute Coronary Syndrome, Heart failure or other admission * Severe mitral or aortic stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent of patients meeting new diagnostic criteria for HFpEF | Up to 5 years |
Countries
Canada
Outcome results
None listed