Skip to content

The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.

Sustainable Working Life With Reduced Stress Levels - The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02051127
Acronym
ASTI
Enrollment
119
Registered
2014-01-31
Start date
2013-01-31
Completion date
2017-04-03
Last updated
2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers, Sedentary Lifestyle

Keywords

Exercise, Physical Fitness, Stress, Psychological, Cognition, Psychophysiology, Ergometry, Exercise Test, Sedentary Lifestyle

Brief summary

One of the biggest challenges of today is the high stress levels among employees in companies and organizations. Physical exercise may be an effective preventive measure for stress-related problems. This relatively simple and inexpensive action is believed to be important for increasing and maintaining work ability and reduce the cost of stress-related ill health in the workplace. The aim is to investigate how regular physical exercise affects the individual's ability to mentally and physiologically cope with stress. Acute stress physiological responses are measured before and after a 6 -month intervention, where 100 untrained individuals are randomized to either regular physical exercise or a control group. The hypothesis is that exercise leads to lesser activation of the individual's stress physiological systems and to an efficient physiological protection system. Mental ability to handle stress is also studied as well as possible effects on the brain's cognitive functions. From a work perspective, cognitive impairment due to high exposure to stress is a major problem leading to substantial costs in businesses and organizations as a result of reduced performance and production. We believe that physical activity can alter and mitigate individual stress reactions. This study brings new knowledge that can contribute to increased motivation to prioritize physical activity in everyday life. The study could also provide evidence for businesses and organizations of the benefits of engaging in interventions and fitness initiatives to facilitate/enable increased physical activity in daily life for its employees. With an aging population, we are expected to work longer, which poses a challenge as the ability to manage stress and maintain cognitive abilities decline with age. For older employees, regular physical activity could be an important factor directly affecting the prospects for a sustainable working life.

Interventions

OTHERExercise

Physical training Duration: 45-60 minutes Frequency: 3 times per week Intensity: mean heart rate \> 75% of maximum heart rate determined by exercise test before start of the intervention

Sponsors

Vastra Gotaland Region
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* Self-reported good health * Sedentary * Work or study at least 50%

Exclusion criteria

* Diabetes * Cardiovascular disease * Blood pressure \> 140/90 * Psychiatric disease * Anemia * Medication with substances that could affect any of the outcome measures

Design outcomes

Primary

MeasureTime frameDescription
Cortisol responses to acute psychosocial stress.6 months after start of interventionSerum cortisol (nmol/l) profile after exposure to the Trier Social Stress Test (TSST).

Secondary

MeasureTime frameDescription
Cognitive function6 months after start of interventionPerformance of the CNS Vital Signs (CNSVS) cognitive test battery.
Self-reported stress sensitivity and symptoms6 and 12 months after start of interventionAssessed with the Perceived Stress Scale (PSS), Coping Inventory for Stressful Situations (CISS), Shirom Melamed Burnout questionnaire (SMBQ), Hospital Anxiety and Depression scale (HAD) and Patient Health Questionnaire (PHQ-15).
Adrenocorticotropic hormone (ACTH) response to psychosocial stress6 months after start of interventionACTH in plasma (pmol/L) after exposure to the TSST
Dehydroepiandrostreone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) response to psychosocial stress6 months after start of the interventionDHEA(S) in serum (µmol/L) after exposure to the TSST

Other

MeasureTime frameDescription
Autonomic responses to acute psychosocial stress6 months after start of interventionHeart rate and blood pressure during and after the Trier Social Stress Test (TSST).
Neuroendocrine and autonomic responses to exercise test6 months after start of intervention

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026