Port-Wine Stain
Conditions
Brief summary
The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.
Detailed description
The researcher can detect the defects in nervous system innervation to cutaneous blood vessels contribute to the pathogenesis of Port Wine Stain . Unveiling the pathogenic mechanisms of PWS is crucial to the design of new therapeutic strategies and can use the results to improve current PWS therapeutic outcomes.
Interventions
OTHERBiopsy sample from Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark
Sponsors
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or female of all ages. * Not pregnant. * Has diagnosis of port wine stain on the arms, legs, chest, bac. * Ability to understand and carry out subject instructions. * Subject willing to have skin biopsies on port wine stain and normal skin areas.
Exclusion criteria
* Pregnant women. * Port Wine Stain on the face. * History of skin cancer. * Current participation in an investigational drug evaluation * Concurrent use of known photosensitizing drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization of Port Wine Stain Birthmark tissue sample | up to 4 weeks |
Countries
United States
Outcome results
None listed