Infertility
Conditions
Keywords
IVF, ICSI, Asthenospermia, pentoxyphylline, Spermatozoa
Brief summary
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.
Interventions
BIOLOGICALPXN sperm treatment
immotile sperm activation with PXN
BIOLOGICALSperm activation with PXN and oocyte activation
Sponsors
Rambam Health Care Campus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Women up to 35 years of age * immotile sperm * At least 6 mature eggs
Exclusion criteria
* globozoospermia * Freeze all cycles because of OHSS risk.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy | One month post oocyte retrieval | Demonstration of fetal heart activity 1 month post oocyte retrieval. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | One day post oocyte retrieval | Normal, 2 pronuclei, zygote one day post ICSI |
Countries
Israel
Outcome results
None listed