The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02050945

Enrollment

Registered

2014-01-31

Start date

2014-01-31

Completion date

2015-03-31

Last updated

2015-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Exercise, Resistance Training

Brief summary

The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that: Resistance training is superior to endurance training in patients with COPD

Interventions

BEHAVIORALResistance training

BEHAVIORALEndurance training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* FEV1/FVC fixed ratio \<0.70, FEV1: \<60% of predicted and MRC \> or equal to 3 * Arterial oxygen saturation at rest\> 90%, BMI \>18, LVEF\> 45. * Age: 40 - 80 years The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.

Exclusion criteria

* Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.

Design outcomes

Primary

Measure	Time frame	Description
Skeletal muscle function	At baseline and after 8 weeks of traning	Muscle biopsy

Secondary

Measure	Time frame	Description
Flow mediated dilation	Change from baseline at 8 weeks	Endothelium function
Body composition	Change from baseline at 8 weeks	DEXA scan
6 min walking test	Change from baseline at 8 weeks	—
Health Related Quality of Life - COPD assessment test (CAT)	Change from baseline at 8 weeks	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026