Breast Cancer
Conditions
Keywords
Must have registered with the ICORG 06-31 TAILORx trial
Brief summary
This is an exploratory, translational, non-interventional and multi-centre biobank. The aim of the development of such a biobank is to identify potential biomarkers that are indicative of disease relapse.
Detailed description
The primary objective is to develop a biobank, tissue microarrays (TMAs) and full face sections, which will be used to identify candidate/ novel biomarkers prognostic for disease relapse and predictive for endocrine and/or chemotherapy resistance. The secondary objectives are: * To validate emerging signatures/biomarkers identified. * To develop new assays for the breast cancer clinic.
Interventions
None listed
Sponsors
Cancer Trials Ireland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients that were registered with the ICORG 06-31 TAILORx trial and participated in trial arms * Patients with adequate tumor tissue available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease relapse, endocrine and/or chemotherapy resistance prognosis | For duration of follow up, expected 10 years | A biobank, TMAs and full face sections, will allow for the identification of candidate/novel biomarkers prognostic for disease relapse and predictive for endocrine and/or chemotherapy resistance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Signature/biomarkers | For the duration of follow up, expected 10 years | Validation of emerging signature/biomarkers |
Countries
Ireland
Outcome results
None listed