Hemodynamic Effects of Stored Blood Transfusion in Intensive Care Patients

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02050230

Enrollment

Registered

2014-01-30

Start date

2014-01-31

Completion date

2016-06-30

Last updated

2016-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Hypertension

Keywords

transfusion, pulmonary hypertension, intensive care medicine

Brief summary

Transfusion of stored blood has been associated with increased pulmonary vascular resistance in lambs. The investigators hypothesize that transfusion of one unit of red blood cells stored under standard conditions in intensive care patients will increase pulmonary arterial pressure and pulmonary vascular resistance to a greater extent than will one unit of fresh red blood cells.

Interventions

BIOLOGICALBlood transfusion

One unit of red blood cells will be transfused over the course of 20 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. The patient has a pulmonary artery catheter in place 2. Transfusion of 1 unit of packed red blood cells indicated for standard intensive care therapy 3. The patient has an arterial catheter

Exclusion criteria

1. Age \< 18 years 2. Clinical prediction that the patient will not survive at least 48 hours 3. Acute bleeding: \> 2 units of packed red blood cells/hour 4. Vasopressor use: noradrenalin \> 0.2 μg/kg/min or any use of adrenalin within 6 hours of inclusion into the study 5. Therapy with inhaled NO, inhaled prostacyclin, or phosphodiesterase-5-inhibitors 6. Sepsis

Design outcomes

Primary

Measure	Time frame
Pulmonary arterial pressure	Change from baseline to immediately after transfusion (time frame of 20 min)
Pulmonary vascular resistance	Change from baseline to immediately after transfusion (time frame of 20 min)

Secondary

Measure	Time frame
Systemic pressure	Change from baseline to immediately after transfusion (time frame of 20 min)
Systemic vascular resistance	Change from baseline to immediately after transfusion (time frame of 20 min)

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026