Knee Osteoarthritis
Conditions
Brief summary
The objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. Fourteen patients with unilateral knee osteoarthritis were recruited. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Medical Outcome Study Short Form-36 (MOS-SF36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.
Interventions
A solution of triamcinolone 40 mg (Kenalog) mixed with 3 cc of 2% xylocaine without epinephrine.
Sponsors
Laval University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 50 years old or more * Medial knee osteoarthritis (Kellgren & Lawrence Grade I to III)
Exclusion criteria
* Intra-articular injection during the last six months * Isolated femoro-patellar arthritis * Rheumatoid arthritis * Knee instability * Spinal stenosis * Lower limb fracture over the last year * Lower limb surgery in the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Knee pain | Change from Baseline at 2, 4 and 6 weeks |
| Change in physical activity | Change from baseline at 2, 4 and 6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in function and quality of life | Change from baseline at 2, 4 and 6 weeks | Assessment with WOMAC and MOS-SF36 questionnaires |
| Change in Spatiotemporal gait parameters | Change from Baseline at 2, 4 and 6 weeks | Gait symmetry was verified with regards to the swing and stance phase durations and step length |
Countries
Canada
Outcome results
None listed