Neoplasia
Conditions
Keywords
lung cancer, breast cancer
Brief summary
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in screening cancer patients in health examination. Trained dogs will sniff serum from participants who are attending the annual health examination to identify potential or high risk subjects, and the results will be compared with the outcome of the traditional health examination, and the high risk subjects will be followed periodically for at least five years.
Interventions
None listed
Sponsors
Chang-Qing Gao
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* old than 20 years * currently without cancer diagnosed with pathological examination * allow the study team to examine his/her case history and incoming record
Exclusion criteria
* cancer patients with pathological diagnosis * who does not allow the study team to examine his/her case history and incoming record
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and specificity in screening cancer patients | up to 5 years | The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination or the currently used methods as non-cancer subjects or at the end of the study, 5 years later still without cancer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavior patterns of sniff dogs to different diseases | up to 5 years | The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination. |
Other
| Measure | Time frame | Description |
|---|---|---|
| The substances used by the sniff dogs to identifying tumors | up to 5 years | GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from normal subjects, the suspected VOCs will be tested by the dog for conformation. |
Countries
China
Contacts
Primary ContactChang-Qing Gao, MD PhD
Backup ContactYa-Qin Wang, MD PhD
Outcome results
None listed