ICU Patients With Indication of Sedation
Conditions
Keywords
Pharmacokinetics, Sevoflurane, Burn, Sedation
Brief summary
Comparing a pharmacokinetic model of a short sevoflurane sedation in burn ICU patients with control ICU patients.
Detailed description
Prospective clinical study in ICU with sedated ventilated patients with sevoflurane with the AnaConda® system, establishing pharmacokinetic model of sevoflurane and its metabolites (hydroxyfluroisopropanol, fluoride) comparing burn and non burn ICU patients
Interventions
DRUGShort term sedation with sevoflurane in ICU
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients ventilated requiring invasive procedure in ICU * Stable respiratory and hemodynamic conditions * Consent of patients or family * Arterial line * Burn patients : burn area between 20 and 50% (3rd degree) OR non burn patients
Exclusion criteria
* BMI \<30 * Sevoflurane anaphylaxia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of plasmatic concentrations of sevoflurane | at 5min, 15 min, 60 min and just before the end of sedation. |
Secondary
| Measure | Time frame |
|---|---|
| Determination of plasmatic concentrations of HFIP and fluoride | at 5min, 15 min, 60 min and just before the end of sedation. And 5min, 10 min, 30 min, 60 min and 120 min after the end of sedation |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORSébastien PERBET
University Hospital, Clermont-Ferrand
Outcome results
None listed