Other Specified Respiratory Problems in Fetus or Neonate
Conditions
Brief summary
Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that uses the diaphragm's normal electrical activity to deliver a mechanically supported breath. The amount of support provided is determined in part by the NAVA level, where a higher NAVA level will provide higher level of support and unload more of the work of the diaphragm. The purpose of this study is to compare the optimal NAVA level in neonates while on mechanical ventilation while intubated and after being extubated.
Detailed description
Baseline measurements will be taken. The NAVA titration study will then be done. The NAVA level will be set at a starting value of 0.1 cm H2O/mcV and systematically increased by 0.5 cm H2O/mcV every three minutes to a maximum of 3 cmH2O/mcV. Once the NAVA titration study has been completed, the patient will be extubated. There will be a stabilization period following extubation (15-30 minutes), and then the NAVA titration study will be repeated.
Interventions
PROCEDURENAVA level
Peak inspiratory pressure will be measured at each NAVA level
Sponsors
ProMedica Health System
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
23 Weeks to 40 Weeks
Healthy volunteers
No
Inclusion criteria
* Neonates on NAVA ventilation
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in breakpoint in intubated and extubated patients | 20 minute study pre and post extubation | NAVA titration study will be done pre and post extubation to determine and then compare the breakpoint. |
Countries
United States
Outcome results
None listed