Migraine With Aura
Conditions
Keywords
migraine with aura, migraine, case-control study, magnetic resonance imaging, brain diseases
Brief summary
The purpose of this study is to investigate whether a particular form of migraine, migraine with aura, is associated with structural changes in the brain
Interventions
None listed
Sponsors
Glostrup University Hospital, Copenhagen
Copenhagen University Hospital, Hvidovre
University of Southern Denmark
Odense University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* female * case (migraine with aura), co-twin to case, or control (migraine-free) * residency in Denmark * no severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders
Exclusion criteria
* male * residency outside Denmark * registered in Civil Registry as not to be contacted by researchers * severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders * mobile metal parts or other contraindication for MRI * weight of 130+ kilograms * pregnancy * subjects that wished not to be informed about abnormal findings on MRI * chronic tension-type headache, medication overuse headache, or cluster headache (diagnosed through physician interview) * frequent tension-type headache (control group only, self-reported or diagnosed through physician interview)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of white matter hyperintensities or subclinical ischaemic stroke confirmed by MRI | At time of MRI |
Secondary
| Measure | Time frame |
|---|---|
| Evidence of other structural and functional changes in brain | At time of MRI |
Outcome results
None listed