Prognostic Value of Sympathetic Modulation in Patients With Heart Failure

Prognostic Value of Oscillatory Pattern of Sympathetic Nerve Activity Muscle in Patients With Heart Failure

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02047409

Enrollment

160

Registered

2014-01-28

Start date

2013-10-31

Completion date

2016-10-31

Last updated

2015-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Brief summary

The purpose of this study is to determine whether oscillatory pattern of sympathetic nerve activity muscle is an efficient index for the prognosis of patients with heart failure.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients with systolic heart failure and New York Heart Association (NYHA) * Ischemic, hypertensive, or idiopathic etiology * Left ventricular ejection fraction less than 40%

Exclusion criteria

* Neuromuscular, Orthopedic, Neurologic and Pulmonary Diseases * Renal failure * Diabetes mellitus type II

Design outcomes

Primary

Measure	Time frame	Description
Peripheral autonomic control	12 months	Evaluate if the reduction in the oscillatory pattern of muscle sympathetic nerve activity is associated with morbidity and mortality in patients with heart failure in a clinical follow-up 12 months

Secondary

Measure	Time frame
Arterial baroreflex control	12 months
Blood inflammatory markers	12 months
Cardiac and peripheral autonomic control	12 months
Functional Capacity	12 months

Countries

Brazil

Contacts

Primary ContactEdgar Toschi Dias, PhD

edgar.dias@incor.usp.br55 11 2661-5099

Backup ContactMaria Urbana P B Rondon, PhD

urbana@usp.br55 11 3091-8784

Outcome results