Renal Function Determination in Patients With Liver Cirrhosis

Renal Function Determination With Creatinine and Cystatin C Dependent Formulas Compared to Gold Standard DTPA-TC-99 (Diethylene-triamine-pentaacetate- Technetium-99) in Mexican Cirrhotic Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02047240

Enrollment

Registered

2014-01-28

Start date

2013-04-30

Completion date

2016-04-30

Last updated

2016-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis

Keywords

liver cirrhosis, glomerular filtration, cystatin C

Brief summary

We have several ways to appropriately determine renal function in healthy patients and in several diseases, in cirrhotic population we dont have a precise tool that has sufficient precision that reflects glomerular function, although it has been reported that cystatin C, because of its nature could improve diagnostic accuracy to determinate the renal function in this population. The investigators hypothesize that glomerular filtration obtained from cystatin-C-derived formulas are more accurate when compared to creatinine-derived formulas with DTPA-Tc99 (diethylene-triamine-pentaacetate- technetium-99) as gold standard.

Detailed description

The aim of the study is to determine if the formulas for glomerular filtration are close to the estimation of actual renal function in mexican cirrhotic patients of different etiologies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Liver cirrhosis * Stability in creatinine levels in the previous three months (variation \<0.3 mg/dL) * Signed informed consent

Exclusion criteria

* Pregnancy * Hepatocellular carcinoma * Cerebrovascular events * Decompensated heart failure * Drugs that modify serum creatinine levels * Renal replacement therapy

Design outcomes

Primary

Measure	Time frame	Description
Levels of glomerular filtration through several formulas in cirrhotic patients	Baseline	Determination of glomerular filtration through several formulas dependent of creatinine and cystatin C and the gold standard

Countries

Mexico

Outcome results