Chronic Heart Failure, Reconditioning to Effort
Conditions
Brief summary
This is a single-centre open randomized parallel-group study. Patients will be selected at random to be included in group 1: eccentric rehabilitation or group 2: conventional rehabilitation. In addition, a group of healthy volunteers aged between 20 and 85 years will also be recruited. This group will make it possible to evaluate, during the two exercise sessions, mechanisms of adaptation linked to eccentric exercise vs concentric exercise.
Interventions
OTHERinitial evaluation
OTHERPeriod of cardiac rehabilitation
OTHERfinal evaluation
OTHERConcentric and eccentric exercise sessions
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 85 Years
Inclusion criteria
Patients : * Patients who have provided written informed consent * Patients with national health insurance cover * Men or women aged between 45 and 85 years with stabilized chronic heart failure (ischemic or dilated cardiopathy) for at least one month, New York Heart Association stage\> 2. * Echocardiographic left ventricular ejection fraction (Simpson method) \< 45% OR N-terminal-ProBNP \> 3 x upper limit of normal\* (\*= 125pg/ml for the CHU laboratory). * First period of rehabilitation for chronic heart failure. Healthy volunteers: * Subjects who have provided written informed consent * Subjects with national health insurance cover * Men or women aged between 18 and 85 years.
Exclusion criteria
Patients: * persons without national health insurance cover * Severe obstructive cardiopathy, * severe aortic valve stenosis, * severe progressive heart rhythm or conduction disorders not corrected with a pacemaker, discovered at the initial effort test * intra-cavitary thrombus, * severe pulmonary artery hypertension (systolic pulmonary arterial hypertension \>70mmHg), * recent history of venous trombo-embolism (last 3 months), * impaired executive function making it impossible to understand and follow reconditioning programme (Mini Mental Test \< 24), * heart transplant, * associated medical disorders that could predominately impair functional capacity compared with the chronic heart failure (examples: respiratory insufficiency, non-stabilized metabolic disorders such as progressive kidney failure, severe asthenia related to a severe non-stabilized disorder such as neoplasia, systemic disease…). associated chronic motor deficit of a neurological origin (example: sequelae of a cerebrovascular accident), an osteo-articular origin (example: impairment due to Rheumatoid arthritis), of a peripheral vascular disease (example: peripheral artery disease, venous disease, lymphedema) will not be included in the
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evolution of performance in the 6-minute walk test between the initial assessment and the final assessment of a reconditioning programme | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Evolution of functional and physiological capacities and tolerance criteria | 12 weeks |
Countries
France
Outcome results
None listed