Subfertility
Conditions
Brief summary
Corifollitropin alfa has been shown to result in significantly more oocytes compared to daily recombinant follicle stimulating hormone (recFSH) (Devroey et al., 2009), probably due to the higher circulating FSH activity during the first days of stimulation. For this reason, the use of corifollitropin alfa might be beneficial in poor responders in whom the number of oocytes retrieved is crucial for success. The purpose of this study is to evaluate the effectiveness of corifollitropin alfa treatment compared to daily recFSH in terms of the number of oocytes retrieved in a defined population of poor responder patients undergoing intracytoplasmic sperm injection (ICSI) using gonadotrophin releasing hormone (GnRH) antagonists.
Interventions
DRUGCorifollitropin alfa
DRUGrFSH
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Proven poor responders of couples with an indication for COS 2. ≥ 18 and \< 45 years of age 3. BMI ≥ 18 and ≤ 32 kg/m2 4. Regular spontaneous menstrual cycle (24-35 days) 5. Availability of ejaculatory sperm (use of donated and/or cryo-preserved sperm is allowed)
Exclusion criteria
1. PGD or PGS 2. TESE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total number of retrieved oocytes | 36 h after human chorionic gonadotrophin (hCG) administration |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate (evidence of intrauterine sac with fetal heart activity at 6-8 weeks of gestation) | At 6-8 weeks of gestation |
| Number of embryos transferred | 2 days following oocyte retrieval |
Countries
Greece
Outcome results
None listed