Arrhythmia
Conditions
Brief summary
Heart failure patients represent a group of individuals at higher risk for cardiac arrhythmias. There is a perception that caffeine consumption may represent an increase in this risk. Although the medical staff and health professionals suggest a reduction in the intake of this substance to patients considered at risk, there is no scientific proof for this recommendation. Some animal studies suggest a possible association between arrhythmias and caffeine use with higher doses, but this finding did not appear in human studies. In particular, little is known about the association between caffeine consumption and arrhythmias in patients with heart failure, especially at higher doses of consumption. More specific and safe guidelines on caffeine consumption are needed.
Interventions
DIETARY_SUPPLEMENTcaffeine
Five doses of 100mg of caffeine diluted in 100 ml of decaffeinated coffee. One dose every hour for five hours
Sponsors
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Luis Eduardo Paim Rohde
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Heart failure in NYHA functional class I-III * LV Ejection fraction \<45% * Age \> 18 y.o. * Cardio-defibrillator implanted with normal functioning with at least 30 days.
Exclusion criteria
* Impossibility of take caffeine * Inability to perform an exercise test * Initial use of amiodarone in the last 2 months * Unstable ventricular arrhythmias, shock or ATP in the last 60 days * Hospitalization in the last two months due to decompensated heart failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arrhythmias | 6 hours |
Countries
Brazil
Contacts
Primary ContactPriccila Zuchinali
Outcome results
None listed