Calcium Ionophore Solution Can Increase Fertilization Rate in Patients During Intracytoplasmic Sperm Injection(ICSI) Who Have Poor Ovarian Reserve?

Effect of Calcium Ionophore Solution on Fertilization Rate During ICSI Cycles of Poor Ovarian Reserve Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02045914

Enrollment

162

Registered

2014-01-27

Start date

2014-01-31

Completion date

2014-08-31

Last updated

2014-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertilization Failure

Keywords

calcium ionophore, fertilization rate, poor ovarian reserve

Brief summary

The aim of this study is to evaluate calcium ionophore solution on fertilization rate of patients during intracytoplasmic sperm injection who have poor ovarian reserve

Detailed description

During ICSI cycle , female patients who have poor ovarian reserve have low oocyte numbers. So by calcium ionophore solution which we know that it can increase fertilization rate in males who have azospermia or globozoospermia. we planned to check if this solution can increase fertilization rate also in poor ovarian reserve patients?

Interventions

OTHERcalcium ionophore solution

After microinjection of sperm into the oocyte, oocytes are incubated for 15 minutes in a 30 microlitre droplet of calcium ionomycin solution

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

23 Years to 39 Years

Healthy volunteers

Inclusion criteria

* infertile couples who have no male factor infertility * infertile females who are poor ovarian reserve

Exclusion criteria

* infertile couples who have male factor infertility * infertile female who have endometriosis

Design outcomes

Primary

Measure	Time frame	Description
calcium ionophore solution effect on fertilization rate	18 hours	Before Intracytoplasmic sperm injection adding calcium ionophore solution to the medium can increase fertilization rate of oocytes or not?

Secondary

Measure	Time frame	Description
Calcium ionophore solution increase on going pregnancy rate	up to 21 weeks	İf the calcium ionophore can increase fertilization rate , pregnancy rate up to 20 weeks, can increase or not?

Other

Measure	Time frame	Description
calcium ionophore can decrease fertilization rate	18 hours	To detect if calcium ionophore can affect fertilization rate in a reverse manner than expected

Countries

Turkey (Türkiye)

Contacts

Primary ContactPinar Caglar Aytac, MD

pinarcag1976@yahoo.com905052796784

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026