Cancer Brain, Cancer Head &Neck, Cancer Liver, Cancer Pelvis
Conditions
Keywords
Cancer, MRI
Brief summary
Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.
Interventions
PROCEDUREMRI Group
A single research MRI
Sponsors
University of Michigan Rogel Cancer Center
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients ≥18 years of age * A working diagnosis of malignancy in the liver, brain, H&N, or pelvis * A plan to treat with radiotherapy
Exclusion criteria
* Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of participants with MRI images suitable for analyses | Day One | Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care. |
Countries
United States
Outcome results
None listed