Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma Patients

Study of Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma Patients Receiving Concurrent Chemo-radiotherapy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02044562

Enrollment

Registered

2014-01-24

Start date

2013-09-30

Completion date

2014-09-30

Last updated

2014-01-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal Carcinoma

Keywords

dietary nitrate, radiotherapy, nasopharyngeal carcinoma

Brief summary

The purpose of this study is to evaluate whether dietary nitrate supplementation could improve the plasma nitrate levels for nasopharyngeal carcinoma patients receiving concurrent chemo-radiation therapy.

Detailed description

Twenty patients diagnosed as nasopharyngeal carcinoma will be recruited. A 70 ml beetroot juice containing 0.45g nitrate or placebo will be provided to the patients for 7 days at the end of the radiotherapy . The plasma nitrate levels will be determined before radiotherapy, before intervention and after intervention.

Interventions

DIETARY_SUPPLEMENTnitrate supplementation

A 70 ml beetroot juice containing 0.45g nitrate will be provided to the patients for 7 days at the end of the radiotherapy.

DIETARY_SUPPLEMENTPlacebo

A 70 ml placebo containing 0 g nitrate will be provided to the patients for 7 days at the end of the radiotherapy.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patients with newly diagnosed stages III-IVb (UICC 2002) nasopharyngeal carcinomas, will be recruited.

Exclusion criteria

* Patients with local invasion or metastatic foci in salivary glands, detected by MRI and PET-CT prior to treatment, were excluded, as were patients suffering from diseases, such as Sjogren's syndrome, or with a history of surgery to major salivary glands, or prior head and neck radiotherapy.

Design outcomes

Primary

Measure	Time frame	Description
plasma nitrate level	one day after nitrate supplementation	The plasma nitrate level will be determined one day after nitrate supplementation.

Secondary

Measure	Time frame	Description
quality of life	one day after nitrate supplementation	The quality of life will be assessed one day after nitrate supplementation.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026