Blood Loss, Postpartum Hemorrhage
Conditions
Keywords
Carbetocin, syntometrine, postpartum hemorrhage, cesarean section
Brief summary
to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after cesarean section
Detailed description
A double blind randomized study conducted on 450 pregnant subjected randomly either to single 100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (300 women) after fetal extraction and before placental removal. Prevention of postpartum haemorrhage (PPH) after cesarean section (CS) had been evaluated by measurement of drop of Hemoglobin and hematocrit, incidence of PPH and number of subjects needed additional oxytocic
Interventions
DRUGcarbetocin
Oxycontin analogue
DRUGSyntometrine
Uterotonins
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* All participants are at 37 - 40 weeks of gestational age * Noncomplicated pregnancy.
Exclusion criteria
* Participants with placenta previa * Patients with coagulopathy * preeclamptic women * known sensitivity to oxytocin or methergine were excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevention of post partum hemorrhage after CS | 24 hours | Number of participants experienced postpartum hemorrhage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| side effects of drugs used | 24 hours | Number of subjects experienced Hemodynamic changes (blood pressure , pulse and respiratory rate ) , GIT side effects as nausea , vomiting and metallic taste, Vasomotor effects as flushing, headache , itching |
Countries
Egypt
Outcome results
None listed