Subfertility
Conditions
Keywords
IVF, hCG, oocyte retrieval, time interval
Brief summary
During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH. The hCG is administered when more than three follicles ≥17mm in mean diameter have developed. The time interval between hCG administration and oocyte retrieval is of critical importance since the time after luteinizing stimulus is a period of intense processes including the start of luteinization, expansion of cumulus cells and oocyte meiotic maturation. The commonly practiced hCG administration time of 33 to 36 h in most IVF cycles aims to avoiding spontaneous ovulation before oocyte retrieval. However, several studies have shown that significantly more high quality embryos have been obtained with a prolonged hCG-to-oocyte interval of 38 h. It has been hypothesized that longer interval would be beneficial in improving oocyte quality and achieving optimal maturation. Currently there are no data on the effect of the time interval between hCG administration and oocyte retrieval on IVF outcome in GnRH antagonist cycles. The aim of this study is to determine whether there is any difference in in vitro fertilization outcome when oocyte retrieval takes place at 36 h or 38 h following hCG administration
Interventions
PROCEDUREOocyte retrieval will be performed 36 h or 38 h after hCG administration
Oocyte retrieval will be performed 36 h or 38 h after hCG administration
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing fresh IVF cycle with recombinant FSH and GnRH antagonists * regular spontaneous menstrual cycle (24-35 days) * age ≤ 43 years * FSH ≤ 20 IU/L
Exclusion criteria
* History of previous ovarian surgery * Women with Stage III-IV Endometriosis * Women undergoing natural cycle IVF
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| retrieval rate (cumulus-oocyte complexes/ follicles> 11 mm) | up to 38 h after hCG administration |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate (evidence of intrauterine sac with fetal heart activity at 6-8 weeks of gestation) | At 6-8 weeks of gestation |
| Total number of oocytes retrieved | up to 38 h after hCG administration |
Countries
Greece
Outcome results
None listed